Article
Association between a polymorphism in the human programmed death-1 (PD-1) gene and cytomegalovirus infection after kidney transplantation.
Journal of medical genetics - 1 Jan 2010
Hoffmann Thomas W, Halimi Jean-Michel, Büchler Mathias, Velge-Roussel Florence, Goudeau Alain, Al-Najjar Azmi, Marliere Jean-Frédéric, Lebranchu Yvon, Baron Christophe
Abstract excerpt
BACKGROUND: Cytomegalovirus (CMV) infection is the most frequent infectious disease following organ transplantation. Strategies to prevent this infection remain a matter for debate, and discovering genetic risk factors might assist in adapting preventive strategies. By inhibiting IFNgamma production, programmed death 1 (PD-1) has a crucial role in anti-CMV immune response. A single nucleotide polymorphism (SNP)...
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