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Article

TLR9 and CYP3A5 polymorphisms influence the risk of BK polyomavirus reactivation in Chinese kidney transplant recipients.

Microbial pathogenesis - 1 Nov 2026

He Shiyi, Lei Ming, Lv Zhilue, Gao Jinwei, Xie Li

Abstract excerpt

BACKGROUND: Genetic determinants of BK polyomavirus (BKV) reactivation after kidney transplantation are poorly explored. We assessed the associations between polymorphisms in TLR3, TLR9, IL6, and CYP3A5 genes and BKV reactivation risk among Chinese kidney transplant recipients, with BKV DNAuria as the primary endpoint. METHODS: A total of 133 kidney transplant recipients were prospectively enrolled and followed...

Read the complete abstract on PubMed

Topics

Adult
Female
Humans
Male
Middle Aged
BK Virus
China

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cytochrome P-450 CYP3A

DNA, Viral

Genetic Predisposition to Disease

Genotype

Interleukin-6

Kidney Transplantation

Polymorphism, Single Nucleotide

Polyomavirus Infections

Prospective Studies

Toll-Like Receptor 3

Toll-Like Receptor 9

Source

Identifiers

PMID: 42617435
DOI: 10.1016/j.micpath.2026.108785

Genes

TLR9
CYP3A5
IL6
TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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