A polymorphism linked to elevated levels of interferon-γ is associated with an increased risk of cytomegalovirus disease among Caucasian lung transplant recipients at a single center.

doi:10.1016/j.healun.2010.11.008

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Article

A polymorphism linked to elevated levels of interferon-γ is associated with an increased risk of cytomegalovirus disease among Caucasian lung transplant recipients at a single center.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 May 2011

Mitsani Dimitra, Nguyen M Hong, Girnita Diana M, Spichty Kathleen, Kwak Eun J, Silveira Fernanda P, Toyoda Yoshiya, Pilewski Joseph M, Crespo Maria, Bhama Jay K, Abdel-Massih Rima, Zaldonis Diana, Zeevi Adriana, Clancy Cornelius J

Abstract excerpt

BACKGROUND: Single-nucleotide polymorphisms (SNPs) associated with active cytomegalovirus (CMV) infections after lung transplantation have not been identified. METHODS: SNPs associated with varying levels of interferon (IFN)-γ (+874T/A), tumor necrosis factor-α (-308G/A), interleukin-10 (-1082G/A, -819C/T, -592C/A) and interleukin-6 (-174G/C) were characterized for 170 Caucasian lung transplant recipients who...

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PMID: 21239188
DOI: 10.1016/j.healun.2010.11.008

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