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Article

Immunomodulatory Function of Interleukin 28B during primary infection with cytomegalovirus.

The Journal of infectious diseases - 1 Sept 2014

Egli Adrian, Levin Aviad, Santer Deanna M, Joyce Michael, O'Shea Daire, Thomas Brad S, Lisboa Luiz F, Barakat Khaled, Bhat Rakesh, Fischer Karl P, Houghton Michael, Tyrrell D Lorne, Kumar Deepali, Humar Atul

Abstract excerpt

BACKGROUND: Feedback mechanisms between interferons α and λ (IFNs) may be affected by single nucleotide polymorphisms (SNP) in interleukin 28B (IL-28B; IFN-λ3) promoter region and may influence cytomegalovirus (CMV) replication. METHODS: We associated IL-28B SNPs with the risk of CMV replication after transplantation. Next, we examined the effect of IL-28B genotypes on IL-28B, and IFN-stimulated gene (ISG)...

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Identifiers

PMID: 24620020
DOI: 10.1093/infdis/jiu144

Genes

OAS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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