Article
No association of genetic variants in TLR4, TNF-α, IL10, IFN-γ, and IL37 in cytomegalovirus-positive renal allograft recipients with active CMV infection-Subanalysis of the prospective randomised VIPP study.
PloS one - 1 Jan 2021
Mazzola Pascale, Schaeffeler Elke, Witzke Oliver, Nitschke Martin, Kliem Volker, Zortel Max, Wagner Eva-Maria, Schwab Matthias, Hauser Ingeborg A
Abstract excerpt
BACKGROUND: Cytomegalovirus (CMV) infection is amongst the most important factors complicating solid organ transplantation. In a large prospective randomized clinical trial, valganciclovir prophylaxis reduced the occurrence of CMV infection and disease compared with preemptive therapy in CMV-positive renal allograft recipients (VIPP study; NCT00372229). Here, we present a subanalysis of the VIPP study,...
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