Article
Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlas.
Autism research : official journal of the International Society for Autism Research - 1 Feb 2014
Steadman Patrick E, Ellegood Jacob, Szulc Kamila U, Turnbull Daniel H, Joyner Alexandra L, Henkelman R Mark, Lerch Jason P
Abstract excerpt
Magnetic resonance imaging (MRI) of autism populations is confounded by the inherent heterogeneity in the individuals' genetics and environment, two factors difficult to control for. Imaging genetic animal models that recapitulate a mutation associated with autism quantify the impact of genetics on brain morphology and mitigate the confounding factors in human studies. Here, we used MRI to image three genetic...
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