Article
An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum.
Frontiers in neural circuits - 1 Jan 2021
Lai Esther Suk King, Nakayama Hisako, Miyazaki Taisuke, Nakazawa Takanobu, Tabuchi Katsuhiko, Hashimoto Kouichi, Watanabe Masahiko, Kano Masanobu
Abstract excerpt
Neuroligin is a postsynaptic cell-adhesion molecule that is involved in synapse formation and maturation by interacting with presynaptic neurexin. Mutations in neuroligin genes, including the arginine to cystein substitution at the 451st amino acid residue (R451C) of neuroligin-3 (NLGN3), have been identified in patients with autism spectrum disorder (ASD). Functional magnetic resonance imaging and examination of...
Topics
- Animals
- Autism Spectrum Disorder
- Autistic Disorder
- Cell Adhesion Molecules, Neuronal
- Cerebellum
- Humans
- Membrane Proteins
- Mice
- Mutation
- Nerve Tissue Proteins
- Purkinje Cells
- Synapses