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Functional and structural connectome properties in the 5XFAD transgenic mouse model of Alzheimer’s disease

23 Feb 2018

Abstract excerpt

Neurodegeneration in Alzheimer's disease (AD) is associated with amyloid-beta peptide accumulation into insoluble amyloid plaques. The five-familial AD (5XFAD) transgenic mouse model exhibits accelerated amyloid-beta deposition, neuronal dysfunction, and cognitive impairment. We aimed to determine whether connectome properties of these mice parallel those observed in patients with AD. We obtained diffusion tensor...

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PMID: 30215035
DOI: 10.1162/netn_a_00048

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