Article
Quantitative Multi-modal Brain Autoradiography of Glutamatergic, Dopaminergic, Cannabinoid, and Nicotinic Receptors in Mutant Disrupted-In-Schizophrenia-1 (DISC1) Mice.
Molecular imaging and biology - 1 Jun 2015
Kim Jongho, Horti Andrew G, Mathews William B, Pogorelov Vladimir, Valentine Heather, Brasic James R, Holt Daniel P, Ravert Hayden T, Dannals Robert F, Zhou Luewi, Jedynak Bruno, Kamiya Atsushi, Pletnikov Mikhail V, Wong Dean F
Abstract excerpt
PURPOSE: Disrupted-in-schizophrenia-1 (DISC1) is a promising genetic susceptibility factor for major psychiatric conditions, such as schizophrenia. We hypothesized that the mutant DISC1 alters the homeostasis of multi-receptor interactions between dopaminergic [dopamine 2/3 (D(2/3)R)], glutamatergic [metabotropic glutamate 5 (mGluR5)], cannabinoid 1 (CB(1)R), and nicotinic acetylcholine (α4β2-nAChR) receptors in...
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