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Article

Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging.

Human molecular genetics - 15 Apr 2013

Jaaro-Peled Hanna, Niwa Minae, Foss Catherine A, Murai Rina, de Los Reyes Samantha, Kamiya Atsushi, Mateo Yolanda, O'Donnell Patricio, Cascella Nicola G, Nabeshima Toshitaka, Guilarte Tomás R, Pomper Martin G, Sawa Akira

Abstract excerpt

Imaging of the human brain has been an invaluable aid in understanding neuropsychopharmacology and, in particular, the role of dopamine in the striatum in mental illness. Here, we report a study in a genetic mouse model for major mental illness guided by results from human brain imaging: a system...

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Identifiers

PMID: 23314019
DOI: 10.1093/hmg/ddt007
PMCID: PMC3605832

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23314019-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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