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Article

A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling.

The Journal of biological chemistry - 21 Nov 2014

Chung Jon H, Larsen Andrew R, Chen Evan, Bunz Fred

Abstract excerpt

The p53-mediated responses to DNA damage and the Hedgehog (Hh) signaling pathway are each recurrently dysregulated in many types of human cancer. Here we describe PTCH53, a p53 target gene that is homologous to the tumor suppressor gene PTCH1 and can function as a repressor of Hh pathway activati...

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Source

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Identifiers

PMID: 25296753
DOI: 10.1074/jbc.M114.597203
PMCID: PMC4239647

Genes

PTCH1
PTCHD4
SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25296753-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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