Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype.

Cancer biology & therapy - 1 Mar 2013

Chang Tsung-Ming, Hung Wen-Chun

Abstract excerpt

The homeobox transcription factor Prox1 is highly expressed in adult hepatocytes and is involved in the regulation of bile acid synthesis and gluconeogenesis in the liver by interacting with other transcriptional activators or repressors. Recent studies showed that Prox1 could inhibit proliferation of hepatocellular carcinoma (HCC) cells and reduced Prox1 expression was associated with poor prognosis of HCC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Liver Neoplasms

Share to Tumor Burden

Share to Tumor Suppressor Proteins

Share to Twist-Related Protein 1

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 23291986
DOI: 10.4161/cbt.23293
PMCID: PMC3595304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype.PMID 23291986Read ↗

A Homeobox Protein, Prox1, Is Involved in the Differentiation, Proliferation, and Prognosis in Hepatocellular CarcinomaSemantic proximity Read ↗

Impact of Prospero Homeobox-1 (PROX-1) οn the Oncogenic Phenotypes of Hepatocellular Carcinoma Cells.Semantic proximity Read ↗

p53-Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT.Semantic proximity Read ↗

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.Semantic proximity Read ↗

The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and SurvivalSemantic proximity Read ↗

SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.Semantic proximity Read ↗

Hepatocellular carcinoma evades RB1-induced senescence by activating the FOXM1–FOXO1 axisSemantic proximity Read ↗

Identification of p53 regulators by genome-wide functional analysis.Semantic proximity Read ↗

An E2F1/DDX11/EZH2 Positive Feedback Loop Promotes Cell Proliferation in Hepatocellular CarcinomaSemantic proximity Read ↗

Role of p14ARF in TWIST-mediated senescence in prostate epithelial cellsSemantic proximity Read ↗

UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop.Semantic proximity Read ↗

Transcriptional factor Prox1 plays an essential role in the antiproliferative action of interferon-γ in esophageal cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.