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Article

Identification of p53 regulators by genome-wide functional analysis.

Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2004

Huang Qihong, Raya Angel, DeJesus Paul, Chao Sheng-Hao, Quon Kim C, Caldwell Jeremy S, Chanda Sumit K, Izpisua-Belmonte Juan C, Schultz Peter G

Abstract excerpt

The p53 tumor-suppressor protein is a critical mediator of cellular growth arrest and the induction of apoptosis. To identify proteins involved in the modulation of p53 transcriptional activity, a gain-of-function cellular screen was carried out with an arrayed matrix of approximately 20,000 cDNAs. Nine genes previously unknown to be involved in regulating p53 activity were identified. Overexpression of seven of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14990790
DOI: 10.1073/pnas.0308562100
PMCID: PMC373483

Genes

HEY1
TFAP4
HES1
OSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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