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Article

Mutation of the PTCH1 gene predicts recurrence of breast cancer.

Scientific reports - 8 Nov 2019

Wang Chih-Yang, Chang Yung-Chieh, Kuo Yao-Lung, Lee Kuo-Ting, Chen Pai-Sheng, Cheung Chun Hei Antonio, Chang Chih-Peng, Phan Nam Nhut, Shen Meng-Ru, Hsu Hui-Ping

Abstract excerpt

Breast cancer is the most common cancer in women, and some patients develop recurrence after standard therapy. Effective predictors are urgently needed to detect recurrence earlier. The activation of Hedgehog signaling in breast cancer is correlated with poor prognosis. PTCH1 is an essential membrane receptor of Hedgehog. However, there are few reports about mutations in Hedgehog genes in breast cancer. We...

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Identifiers

PMID: 31704974
DOI: 10.1038/s41598-019-52617-4
PMCID: PMC6841698

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