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Article

Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site.

Gene - 14 Apr 2004

Agren Marie, Kogerman Priit, Kleman Marika I, Wessling Martina, Toftgård Rune

Abstract excerpt

The PTCH1 tumor suppressor gene encodes a receptor for secreted hedgehog (HH) ligands and is important for proper proliferation, differentiation and patterning in almost every tissue and organ during embryogenesis. The PTCH1 protein works as a negative regulator of the HH-signaling pathway by repressing downstream signaling by the coreceptor smoothened (SMOH). Mutations in PTCH1 lead to constitutive expression of...

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Source

Identifiers

PMID: 15087129
DOI: 10.1016/j.gene.2004.01.010

Genes

PTCH1
GLI3
SHH
GLI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site.PMID 15087129Read ↗

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Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 proteinSemantic proximity Read ↗

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