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Article

Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics.

Biophysical journal - 7 Oct 2014

Cheng Yuanhua, Lindert Steffen, Kekenes-Huskey Peter, Rao Vijay S, Solaro R John, Rosevear Paul R, Amaro Rommie, McCulloch Andrew D, McCammon J Andrew, Regnier Michael

Abstract excerpt

During β-adrenergic stimulation, cardiac troponin I (cTnI) is phosphorylated by protein kinase A (PKA) at sites S23/S24, located at the N-terminus of cTnI. This phosphorylation has been shown to decrease KCa and pCa50, and weaken the cTnC-cTnI (C-I) interaction. We recently reported that phosphorylation results in an increase in the rate of early, slow phase of relaxation (kREL,slow) and a decrease in its...

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Identifiers

PMID: 25296321
DOI: 10.1016/j.bpj.2014.08.008
PMCID: PMC4190606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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