Article
Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes.
American journal of physiology. Heart and circulatory physiology - 15 Jan 2013
Wijnker Paul J M, Foster D Brian, Tsao Allison L, Frazier Aisha H, dos Remedios Cristobal G, Murphy Anne M, Stienen Ger J M, van der Velden Jolanda
Abstract excerpt
PKA-mediated phosphorylation of contractile proteins upon β-adrenergic stimulation plays an important role in the regulation of cardiac performance. Phosphorylation of the PKA sites (Ser(23)/Ser(24)) of cardiac troponin (cTn)I results in a decrease in myofilament Ca(2+) sensitivity and an increase in the rate of relaxation. However, the relation between the level of phosphorylation of the sites and the functional...
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