Article
The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation.
Circulation research - 25 May 2007
Biesiadecki Brandon J, Kobayashi Tomoyoshi, Walker John S, Solaro R John, de Tombe Pieter P
Abstract excerpt
Striated muscle contraction is regulated by the binding of Ca(2+) to the N-terminal regulatory lobe of the cardiac troponin C (cTnC) subunit in the troponin complex. In the heart, beta-adrenergic stimulation induces protein kinase A phosphorylation of cardiac troponin I (cTnI) at Ser23/24 to alter the interaction of cTnI with cTnC in the troponin complex and is critical to the regulation of cardiac contractility....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.