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Article

Modulation of Structure and Dynamics of Cardiac Troponin by Phosphorylation and Mutations Revealed by Molecular Dynamics Simulations.

The journal of physical chemistry. B - 19 Oct 2023

Yang Zeyu, Marston Steven B, Gould Ian R

Abstract excerpt

Adrenaline acts on β1 receptors in the heart muscle to enhance contractility, increase the heart rate, and increase the rate of relaxation (lusitropy) via activation of the cyclic AMP-dependent protein kinase, PKA. Phosphorylation of serines 22 and 23 in the N-terminal peptide of cardiac troponin I is responsible for lusitropy. Mutations associated with cardiomyopathy suppress the phosphorylation-dependent...

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Identifiers

PMID: 37791815
DOI: 10.1021/acs.jpcb.3c02337
PMCID: PMC10591477

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