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Article

N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle.

The Journal of physiology - 15 Jan 2013

Rao Vijay S, Korte F Steven, Razumova Maria V, Feest Erik R, Hsu Hsiaoman, Irving Thomas C, Regnier Michael, Martyn Donald A

Abstract excerpt

Protein kinase A (PKA) phosphorylation of myofibrillar proteins constitutes an important pathway for β-adrenergic modulation of cardiac contractility. In myofilaments PKA targets troponin I (cTnI), myosin binding protein-C (cMyBP-C) and titin. We studied how this affects the sarcomere length (SL) dependence of force-pCa relations in demembranated cardiac muscle. To distinguish cTnI from cMyBP-C/titin...

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Identifiers

PMID: 23129792
DOI: 10.1113/jphysiol.2012.241604
PMCID: PMC3577517

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