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Article

PKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils.

Biophysical journal - 2 Sept 2014

Rao Vijay, Cheng Yuanhua, Lindert Steffen, Wang Dan, Oxenford Lucas, McCulloch Andrew D, McCammon J Andrew, Regnier Michael

Abstract excerpt

Protein kinase A (PKA) phosphorylation of myofibril proteins constitutes an important pathway for β-adrenergic modulation of cardiac contractility and relaxation. PKA targets the N-terminus (Ser-23/24) of cardiac troponin I (cTnI), cardiac myosin-binding protein C (cMyBP-C) and titin. The effect of PKA-mediated phosphorylation on the magnitude of contraction has been studied in some detail, but little is known...

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Source

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Identifiers

PMID: 25185555
DOI: 10.1016/j.bpj.2014.07.027
PMCID: PMC4156663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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