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Article

Identification of a molecular network regulated by multiple ASD high risk genes.

Human molecular genetics - 21 Jun 2024

Wan Lei, Yang Guojun, Yan Zhen

Abstract excerpt

Genetic sequencing has identified high-confidence ASD risk genes with loss-of-function mutations. How the haploinsufficiency of distinct ASD risk genes causes ASD remains to be elucidated. In this study, we examined the role of four top-ranking ASD risk genes, ADNP, KDM6B, CHD2, and MED13, in gene expression regulation. ChIP-seq analysis reveals that gene targets with the binding of these ASD risk genes at...

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Identifiers

PMID: 38588587
DOI: 10.1093/hmg/ddae058
PMCID: PMC11190613

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