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Article

Candidate gene analysis in human neural tube defects.

American journal of medical genetics. Part C, Seminars in medical genetics - 15 May 2005

Boyles Abee L, Hammock Preston, Speer Marcy C

Abstract excerpt

Biochemical and developmental pathways, mouse models, and positional evidence have provided numerous candidate genes for the study of human neural tube defects. In a survey of 80 studies on 38 candidate genes, few found significant results in human populations through case-control or family-based association studies. While the folate pathway has been explored extensively, only the MTHFR 677C > T polymorphism was...

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Source

Identifiers

PMID: 15816061
DOI: 10.1002/ajmg.c.30048

Genes

MTHFR
NCAM1
UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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