Article
Gene and protein domain-specific patterns of genetic variability within the G-protein coupled receptor superfamily.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2003
Small Kersten M, Tanguay Debra A, Nandabalan Krishnan, Zhan Ping, Stephens J Claiborne, Liggett Stephen B
Abstract excerpt
INTRODUCTION: Guanine nucleotide binding proteins (G-proteins) represent the targets for >50% of all therapeutics. There is substantial interindividual variation in response to agonists and antagonists directed to these receptors, which may, in part, be due to genetic polymorphisms. As a class, the sequence variability of G-protein-coupled receptor (GPCR) genes has not been characterized. STUDY DESIGN: This...
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