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Article

Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Jan 2008

Vidal Ruben, Miravalle Leticia, Gao Xiaoying, Barbeito Ana G, Baraibar Martin A, Hekmatyar Shahryar K, Widel Mario, Bansal Navin, Delisle Marie B, Ghetti Bernardino

Abstract excerpt

Increased iron levels and iron-mediated oxidative stress play an important role in the pathogenesis of many neurodegenerative diseases. The finding that mutations in the ferritin light polypeptide (FTL) gene cause a neurodegenerative disease known as neuroferritinopathy or hereditary ferritinopat...

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Source

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Identifiers

PMID: 18171923
DOI: 10.1523/JNEUROSCI.3962-07.2008
PMCID: PMC2394191

Genes

FTL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18171923-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice.PMID 18171923Read ↗

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