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Article

An alternative approach to multiple testing for methylation QTL mapping reduces the proportion of falsely identified CpGs.

Bioinformatics (Oxford, England) - 1 Feb 2015

Luijk René, Goeman Jelle J, Slagboom Eline P, Heijmans Bastiaan T, van Zwet Erik W

Abstract excerpt

INTRODUCTION: An increasing number of studies investigates the influence of local genetic variation on DNA methylation levels, so-called in cis methylation quantitative trait loci (meQTLs). A common multiple testing approach in genome-wide cis meQTL studies limits the false discovery rate (FDR) among all CpG-SNP pairs to 0.05 and reports on CpGs from the significant CpG-SNP pairs. However, a statistical test for...

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PMID: 25282645
DOI: 10.1093/bioinformatics/btu654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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