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Article

Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci.

Nature communications - 26 Feb 2015

Lemire Mathieu, Zaidi Syed H E, Ban Maria, Ge Bing, Aïssi Dylan, Germain Marine, Kassam Irfahan, Wang Mike, Zanke Brent W, Gagnon France, Morange Pierre-Emmanuel, Trégouët David-Alexandre, Wells Philip S, Sawcer Stephen, Gallinger Steven, Pastinen Tomi, Hudson Thomas J

Abstract excerpt

The interplay between genetic and epigenetic variation is only partially understood. One form of epigenetic variation is methylation at CpG sites, which can be measured as methylation quantitative trait loci (meQTL). Here we report that in a panel of lymphocytes from 1,748 individuals, methylation levels at 1,919 CpG sites are correlated with at least one distal (trans) single-nucleotide polymorphism (SNP) (P<3.2...

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Identifiers

PMID: 25716334
DOI: 10.1038/ncomms7326
PMCID: PMC4351585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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