Article
High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction.
Genome biology - 23 Dec 2015
McClay Joseph L, Shabalin Andrey A, Dozmorov Mikhail G, Adkins Daniel E, Kumar Gaurav, Nerella Srilaxmi, Clark Shaunna L, Bergen Sarah E, Hultman Christina M, Magnusson Patrik K E, Sullivan Patrick F, Aberg Karolina A, van den Oord Edwin J C G
Abstract excerpt
BACKGROUND: Genetic influence on DNA methylation is potentially an important mechanism affecting individual differences in humans. We use next-generation sequencing to assay blood DNA methylation at approximately 4.5 million loci, each comprising 2.9 CpGs on average, in 697 normal subjects. Methylation measures at each locus are tested for association with approximately 4.5 million single nucleotide polymorphisms...
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