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Article

Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status

16 May 2013

Abstract excerpt

Recently, our research team found a strong and significant association between loss-of-function (LOF) mutations in filaggrin (FLG), a gene that encodes a skin barrier protein, in European and Canadian individuals with peanut allergy (PA).1 These mutations result in a barrier defect and have been associated with atopic dermatitis, asthma, and allergic rhinitis.2 This finding represents the strongest genetic risk...

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Identifiers

PMID: 23684069
DOI: 10.1016/j.jaci.2013.03.043

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