Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy.

doi:10.1016/j.jaci.2011.01.031

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Article

Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy.

The Journal of allergy and clinical immunology - 1 Mar 2011

Brown Sara J, Asai Yuka, Cordell Heather J, Campbell Linda E, Zhao Yiwei, Liao Haihui, Northstone Kate, Henderson John, Alizadehfar Reza, Ben-Shoshan Moshe, Morgan Kenneth, Roberts Graham, Masthoff Laury J N, Pasmans Suzanne G M A, van den Akker Peter C, Wijmenga Cisca, Hourihane Jonathan O'B, Palmer Colin N A, Lack Gideon, Clarke Ann, Hull Peter R, Irvine Alan D, McLean W H Irwin

Abstract excerpt

BACKGROUND: IgE-mediated peanut allergy is a complex trait with strong heritability, but its genetic basis is currently unknown. Loss-of-function mutations within the filaggrin gene are associated with atopic dermatitis and other atopic diseases; therefore, filaggrin is a candidate gene in the etiology of peanut allergy. OBJECTIVE: To investigate the association between filaggrin loss-of-function mutations and...

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Identifiers

PMID: 21377035
DOI: 10.1016/j.jaci.2011.01.031
PMCID: PMC3081065

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