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Article

Somatic copy number alterations predict response to platinum therapy in epithelial ovarian cancer.

Gynecologic oncology - 1 Dec 2014

Despierre Evelyn, Moisse Matthieu, Yesilyurt Betül, Sehouli Jalid, Braicu Ioana, Mahner Sven, Castillo-Tong Dan Cacsire, Zeillinger Robert, Lambrechts Sandrina, Leunen Karin, Amant Frédéric, Moerman Philippe, Lambrechts Diether, Vergote Ignace

Abstract excerpt

OBJECTIVE: Platinum resistance remains an obstacle in the treatment of epithelial ovarian cancer (EOC). The goal of this study was to profile EOCs for somatic copy number alterations (SCNAs) as predictive markers of platinum response. METHODS: SCNAs were assessed in a discovery (n=86) and validation cohort (n=115) of high risk stage I or stage II-IV EOCs using high-resolution SNP arrays. ASCAT and GISTIC...

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Source

Identifiers

PMID: 25281495
DOI: 10.1016/j.ygyno.2014.09.014

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AKT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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