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Article

BAD Phosphorylation Determines Ovarian Cancer Chemosensitivity and Patient Survival

17 Aug 2011

Abstract excerpt

PURPOSE: Despite initial sensitivity to chemotherapy, ovarian cancers (OVCA) often develop drug resistance, which limits patient survival. Using specimens and/or genomic data from 289 patients and a panel of cancer cell lines, we explored genome-wide expression changes that underlie the evolution of OVCA chemoresistance and characterized the BCL2 antagonist of cell death (BAD) apoptosis pathway as a determinant...

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PMID: 21849418
DOI: 10.1158/1078-0432.ccr-11-0735

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