Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma.

doi:10.1158/1078-0432.CCR-17-3060

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Article

Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2018

Caumanns Joseph J, Berns Katrien, Wisman G Bea A, Fehrmann Rudolf S N, Tomar Tushar, Klip Harry, Meersma Gert J, Hijmans E Marielle, Gennissen Annemiek M C, Duiker Evelien W, Weening Desiree, Itamochi Hiroaki, Kluin Roelof J C, Reyners Anna K L, Birrer Michael J, Salvesen Helga B, Vergote Ignace, van Nieuwenhuysen Els, Brenton James, Braicu E Ioana, Kupryjanczyk Jolanta, Spiewankiewicz Beata, Mittempergher Lorenza, Bernards René, van der Zee Ate G J, de Jong Steven

Abstract excerpt

Purpose: Advanced-stage ovarian clear cell carcinoma (OCCC) is unresponsive to conventional platinum-based chemotherapy. Frequent alterations in OCCC include deleterious mutations in the tumor suppressor ARID1A and activating mutations in the PI3K subunit PIK3CA In this study, we aimed to identify currently unknown mutated kinases in patients with OCCC and test druggability of downstream affected pathways in OCCC...

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PMID: 29685880
DOI: 10.1158/1078-0432.CCR-17-3060
PMCID: PMC6098697

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