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Genetic alterations and their therapeutic implications in epithelial ovarian cancer.

BMC cancer - 4 May 2021

Lapke Nina, Chen Chien-Hung, Chang Ting-Chang, Chao Angel, Lu Yen-Jung, Lai Chyong-Huey, Tan Kien Thiam, Chen Hua-Chien, Lu Hsiao-Yun, Chen Shu-Jen

Abstract excerpt

BACKGROUND: Genetic alterations for epithelial ovarian cancer are insufficiently characterized. Previous studies are limited regarding included histologies, gene numbers, copy number variant (CNV) detection, and interpretation of pathway alteration patterns of individual patients. METHODS: We sequenced 410 genes to analyze mutations and CNV of 82 ovarian carcinomas, including high-grade serous (n = 37),...

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Identifiers

PMID: 33947352
DOI: 10.1186/s12885-021-08233-5
PMCID: PMC8097933

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