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Article

CFTR chloride channel regulation by an interdomain interaction.

Science (New York, N.Y.) - 15 Oct 1999

Naren A P, Cormet-Boyaka E, Fu J, Villain M, Blalock J E, Quick M W, Kirk K L

Abstract excerpt

The cystic fibrosis gene encodes a chloride channel, CFTR (cystic fibrosis transmembrane conductance regulator), that regulates salt and water transport across epithelial tissues. Phosphorylation of the cytoplasmic regulatory (R) domain by protein kinase A activates CFTR by an unknown mechanism. The amino-terminal cytoplasmic tail of CFTR was found to control protein kinase A-dependent channel gating through a...

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Source

Identifiers

PMID: 10521352
DOI: 10.1126/science.286.5439.544

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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