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Article

CFTR function, pathology and pharmacology at single-molecule resolution

22 Mar 2023

Abstract excerpt

Abstract The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that regulates salt and fluid homeostasis across epithelial membranes 1 . Alterations in CFTR cause cystic fibrosis, a fatal disease without a cure 2,3 . Electrophysiological properties of CFTR have been analysed for decades 4–6 . The structure of CFTR, determined in two globally distinct conformations, underscores its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36949202
DOI: 10.1038/s41586-023-05854-7

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