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Article

Urethral dysfunction in female mice with estrogen receptor β deficiency.

PloS one - 1 Jan 2014

Chen Yung-Hsiang, Chen Chao-Jung, Yeh Shuyuan, Lin Yu-Ning, Wu Yang-Chang, Hsieh Wen-Tsong, Wu Bor-Tsang, Ma Wen-Lung, Chen Wen-Chi, Chang Chawnshang, Chen Huey-Yi

Abstract excerpt

Estrogen has various regulatory functions in the growth, development, and differentiation of the female urogenital system. This study investigated the roles of ERβ in stress urinary incontinence (SUI). Wild-type (ERβ(+/+)) and knockout (ERβ(-/-)) female mice were generated (aged 6-8 weeks, n = 6) and urethral function and protein expression were measured. Leak point pressures (LPP) and maximum urethral closure...

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Identifiers

PMID: 25275480
DOI: 10.1371/journal.pone.0109058
PMCID: PMC4183540

Genes

LPP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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