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Article

Ventral prostate and mammary gland phenotype in mice with complete deletion of the ERβ gene.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2020

Warner Margaret, Wu Wan-Fu, Montanholi Leticia, Nalvarte Ivan, Antonson Per, Gustafsson Jan-Ake

Abstract excerpt

Disagreements about the phenotype of estrogen receptor β (ERβ) knockout mouse, created by removing the DNA-binding domain of the ERβ gene or interruption of the gene with a neocassette (Oliver Smithies ERβ knockout mice [ERβOS-/-]), prompted us to create an ERβ knockout mouse by deleting the ERβ gene with the use of CRISPR/Cas9 technology. We confirmed that the ERβ gene was eliminated from the mouse genome and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32075916
DOI: 10.1073/pnas.1920478117
PMCID: PMC7060692

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