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Article

Proteomic analysis of urethral protein expression in an estrogen receptor α-deficient murine model of stress urinary incontinence.

World journal of urology - 1 Oct 2015

Chen Yung-Hsiang, Chen Chao-Jung, Lin Yu-Ning, Wu Yang-Chang, Hsieh Wen-Tsong, Wu Bor-Tsang, Ma Wen-Lung, Chen Wen-Chi, Tsai Kao-Sung, Wu San-Yuan, Chang Chawnshang, Chen Huey-Yi, Yeh Shuyuan

Abstract excerpt

PURPOSE: The roles of estrogen receptor α (ERα) in stress urinary incontinence (SUI) remain elusive. This study was conducted to understand the molecular mechanism of ERα against SUI. METHODS: Wild-type (ERα(+/+)) and ACTB-cre ERα knockout (ERα(-/-)) female mice were generated. Urethral function and protein expression were measured. Leak point pressures (LPP) and maximum urethral closure pressure (MUCP) were...

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Source

Identifiers

PMID: 25577129
DOI: 10.1007/s00345-014-1474-3

Genes

LPP
ACTB

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