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Estrogen receptor (ER)-β isoforms: A key to understanding ER-β signaling

22 Aug 2006

Abstract excerpt

Estrogen receptor beta (ER-beta) regulates diverse physiological functions in the human body. Current studies are confined to ER-beta1, and the functional roles of isoforms 2, 4, and 5 remain unclear. Full-length ER-beta4 and -beta5 isoforms were obtained from a prostate cell line, and they exhibit differential expression in a wide variety of human tissues/cell lines. Through molecular modeling, we established...

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PMID: 16938840
DOI: 10.1073/pnas.0605676103

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