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Article

Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.

PLoS neglected tropical diseases - 1 Oct 2014

O'Regan Noëlle Louise, Steinfelder Svenja, Venugopal Gopinath, Rao Gopala B, Lucius Richard, Srikantam Aparna, Hartmann Susanne

Abstract excerpt

BACKGROUND: Monocytes and macrophages contribute to the dysfunction of immune responses in human filariasis. During patent infection monocytes encounter microfilariae in the blood, an event that occurs in asymptomatically infected filariasis patients that are immunologically hyporeactive. AIM: To determine whether blood microfilariae directly act on blood monocytes and in vitro generated macrophages to induce a...

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Identifiers

PMID: 25275395
DOI: 10.1371/journal.pntd.0003206
PMCID: PMC4183501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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