Article
NKp46+ natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection.
Frontiers in immunology - 1 Jan 2022
Pionnier Nicolas, Furlong-Silva Julio, Colombo Stefano A P, Marriott Amy E, Chunda Valerine C, Ndzeshang Bertrand L, Sjoberg Hanna, Archer John, Steven Andrew, Wanji Samuel, Taylor Mark J, Turner Joseph D
Abstract excerpt
Lymphatic filariasis and onchocerciasis are major neglected tropical diseases affecting over 90 million people worldwide with painful and profoundly disfiguring pathologies (such as lymphoedema or blindness). Type 2 inflammation is a hallmark of filarial nematode tissue infection and is implicated both in eosinophil dependent immunity and lymphatic or ocular immunopathologies. Type-2 innate lymphoid cells (ILC2)...
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