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Mycobacterium leprae alters classical activation of human monocytes in vitro

11 Mar 2016

Abstract excerpt

BACKGROUND: Macrophages play a central role in the pathogenesis of leprosy, caused by Mycobacterium leprae. The polarized clinical presentations in leprosy are associated with differential immune activation. In tuberculoid leprosy, macrophages show a classical activation phenotype (M1), while macrophages in lepromatous disease display characteristics of alternative activation (M2). Bacille Calmette-Guérin (BCG)...

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PMID: 26973434
DOI: 10.1186/s12950-016-0117-4

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