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Article

Genetic basis of age-dependent synaptic abnormalities in the retina.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2015

Higuchi Hitoshi, Macke Erica L, Lee Wei-Hua, Miller Sam A, Xu James C, Ikeda Sakae, Ikeda Akihiro

Abstract excerpt

Understanding the normal aging process will help us determine the mechanisms of how age-related diseases are caused and progress. A/J inbred mice have been shown to exhibit accelerated aging phenotypes in the retina including increased inflammation and photoreceptor cell degeneration, which resemble human aging symptoms. C57BL/6J (B6) inbred mice are less susceptible for these abnormalities, indicating the...

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PMID: 25273269
DOI: 10.1007/s00335-014-9546-7
PMCID: PMC4428281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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