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Article

New retinal light damage QTL in mice with the light-sensitive RPE65 LEU variant.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2004

Danciger Michael, Lyon Jessica, Worrill Danielle, Hoffman Sara, Lem Janis, Reme Charlotte E, Wenzel Andreas, Grimm Christian

Abstract excerpt

The purpose of this study was to determine the QTL that influence acute, light-induced retinal degeneration differences between the BALB/cByJ and 129S1/SvImJ mouse strains. Five- to 6-week-old F(2) progeny of an intercross between the two strains were exposed to 15,000 LUX of white light for 1 h after their pupils were dilated, placed in the dark for 16 h, and kept for 10-12 days in dim cyclic light before...

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Source

Identifiers

PMID: 15112105
DOI: 10.1007/s00335-003-2336-2

Genes

RPE65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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