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Article

Inflammatory priming predisposes mice to age-related retinal degeneration

16 Jul 2012

Abstract excerpt

Disruption of cellular processes affected by multiple genes and accumulation of numerous insults throughout life dictate the progression of age-related disorders, but their complex etiology is poorly understood. Postmitotic neurons, such as photoreceptor cells in the retina and epithelial cells in the adjacent retinal pigmented epithelium, are especially susceptible to cellular senescence, which contributes to...

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PMID: 22797304
DOI: 10.1172/jci64427

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