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Article

Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

22 Mar 2019

Abstract excerpt

Unraveling the genetic susceptibility of complex diseases such as chronic kidney disease remains challenging. Here, we used inbred rat models of kidney damage associated with elevated blood pressure for the comprehensive analysis of a major albuminuria susceptibility locus detected in these models. We characterized its genomic architecture by congenic substitution mapping, targeted next-generation sequencing, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30900988
DOI: 10.7554/elife.42068

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