Article
Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and Gene-By-Air-Pollution Interaction.
Genetics - 1 Jul 2020
Mak Angel C Y, Sajuthi Satria, Joo Jaehyun, Xiao Shujie, Sleiman Patrick M, White Marquitta J, Lee Eunice Y, Saef Benjamin, Hu Donglei, Gui Hongsheng, Keys Kevin L, Lurmann Fred, Jain Deepti, Abecasis Gonçalo, Kang Hyun Min, Nickerson Deborah A, Germer Soren, Zody Michael C, Winterkorn Lara, Reeves Catherine, Huntsman Scott, Eng Celeste, Salazar Sandra, Oh Sam S, Gilliland Frank D, Chen Zhanghua, Kumar Rajesh, Martínez Fernando D, Wu Ann Chen, Ziv Elad, Hakonarson Hakon, Himes Blanca E, Williams L Keoki, Seibold Max A, Burchard Esteban G
Abstract excerpt
Baseline lung function, quantified as forced expiratory volume in the first second of exhalation (FEV1), is a standard diagnostic criterion used by clinicians to identify and classify lung diseases. Using whole-genome sequencing data from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine project, we identified a novel genetic association with FEV1 on chromosome 12 in 867 African...
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