Article
Low genetic diversity in the locus encoding the Plasmodium vivax P41 protein in Colombia's parasite population.
Malaria journal - 30 Sept 2014
Forero-Rodríguez Johanna, Garzón-Ospina Diego, Patarroyo Manuel A
Abstract excerpt
BACKGROUND: The development of malaria vaccine has been hindered by the allele-specific responses produced by some parasite antigens' high genetic diversity. Such antigen genetic diversity must thus be evaluated when designing a completely effective vaccine. Plasmodium falciparum P12, P38 and P41 proteins have red blood cell binding regions in the s48/45 domains and are located on merozoite surface, P41 forming a...
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