Article
Global genetic diversity of the Plasmodium vivax transmission-blocking vaccine candidate Pvs48/45.
Malaria journal - 12 Apr 2016
Vallejo Andres F, Martinez Nora L, Tobon Alejandra, Alger Jackeline, Lacerda Marcus V, Kajava Andrey V, Arévalo-Herrera Myriam, Herrera Sócrates
Abstract excerpt
BACKGROUND: Plasmodium vivax 48/45 protein is expressed on the surface of gametocytes/gametes and plays a key role in gamete fusion during fertilization. This protein was recently expressed in Escherichia coli host as a recombinant product that was highly immunogenic in mice and monkeys and induced antibodies with high transmission-blocking activity, suggesting its potential as a P. vivax transmission-blocking...
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